Abstract: The developing status of laser homing guided weapons was analyzed.By taking the semi-active laser homing guided projectile as the example and based on the summary of practical working experience ,the laser speckle technique theory was used innovatively to calibrate the optic system in laser homing guided weapon simulation system .After the researches and analyses, the consistency between the simulation and actual working environment was realized theoretically .Moreover,the feasibility was verified by productive practices and real target tests .It provides some practical significance and reference value.