光动力疗法中光动力剂量的数学仿真研究

Photodynamic dose of photodynamic therapy by mathematical simulation

摘要: 通过建立光动力治疗过程中激光、光敏剂、氧及其相互作用关系的数学模型，对组织中光动力剂量进行了模拟，研究了光动力剂量在组织内部分布变化的规律。模拟了激光剂量为50mW/cm2、100mW/cm2、150mW/cm2，光敏剂质量浓度为10mg/kg、20mg/kg、40mg/kg时光动力剂量变化。研究发现光动力剂量在组织内分布是非线性的，大小受激光强度、光敏剂剂量、氧浓度和组织光学参数等因素的影响，且光敏剂浓度的变化对光动力剂量变化的影响尤为明显。

Abstract: Through establishing mathematical relation model of laser, photo-sensitizer and oxygen, photodynamic dose (PDD) in tissue was simulated and its distribution was studied. The change of PDD under the different laser doses of 50mW/cm2，100mW/cm2 and 150mW/cm2 and the photo-sensitizer concentrations of 10mg/kg，20mg/kg and 40mg/kg were simulated. It is concluded that the PDD, an inhomogeneous value in the tissue, changes with many factors such as laser dose, photo-sensitizer and oxygen, and it is obviously effected by the variation of photo-sensitizer concentration.