Abstract: A new alignment system based on the two-beam focus is proposed for the exact installation and alignment of the inertial confinement laser-fusion diagnostic instrument. The alignment theory and system configuration is also discussed. The same structure as Lister microscope is selected for the optical pointing system, whose objective image distance is 180mm, magnification is 10 and NA is 0.25. The two-dimensional adjustable and threedimensional adjusting mechanism which moves along axis of optical pointer is adopted in the design of mechanical structure. The space cone angle of the whole system is 28, which is less than the limitation of 30. It is found that the optical pointer error is 25m by analyzing the error of the system, which can attain the design specification. The instrument can be manipulated easily and so that can be widely used in ICF.