Abstract: The development and application of digital holography has been greatly limited by the insufficient pixel numbers and dynamic range of charge coupled device (CCD). To solve this problem, an arrangement scheme of dual-CCD-s mirroring overlapping position was put forward, based on the information fusion technology. Firstly, the interference image of two spherical waves was used to adjust the dual-CCD-s mirroring overlapping position, and the feasibility of this method was proved. Then in the experiment, the dual-CCD-s position was adjusted in real time by using the off-axis interferometry of spherical wave and plane wave, and the digital interference technology. Finally, the calibration parameters of the dual-CCD-s mirroring overlapping position were given by using the computer digital image processing technology. The experimental results show that, the dual-CCD-s mirroring overlapping position can be precisely adjusted and calibrated by this method, and the error is only 14 m.