Abstract: Aiming at existing de-noising algorithms are often designed for removing single Gaussian noise or impulse noise, an efficient algorithm for mixed noise removal in image was proposed, including space impulse noise removal and wavelet Gaussian noise removal. Firstly, an impulse noise detection algorithm based on median filter was given to filter impulse, and at the same time a lifting wavelet was constructed by lifting original wavelet. Secondly, a threshold method based on lifting wavelet transform for image was applied to de-noising Gaussian noise. At last, simulations were conducted on the presented algorithm, and the simulation result shows that this algorithm can remove mixed Gaussian and impulse noise in image efficiently.