广域视网膜成像技术研究

王业顺; 沈建新

doi:10.5768/JAO201839.0101006

广域视网膜成像技术研究

南京航空航天大学机电学院, 江苏南京 210016

基金项目:

江苏省研究生科研与实践创新计划项目 kfjj20170524

江苏省产学研前瞻性联合研究项目 BY2015003-03

详细信息

作者简介:
王业顺(1991-)，男，江苏徐州人，硕士研究生，主要从事数字化医疗装备设计制造研究。E-mail:wang1554705@qq.com

中图分类号: TN911.73;O439
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出版历程
- 收稿日期: 2017-07-23
- 修回日期: 2017-09-14
- 刊出日期: 2017-12-31

Research of wide-area retinal imaging technique

College of Mechanical and Electrical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China

摘要

摘要: 针对传统眼底照相机检查不到视网膜边缘的缺陷，提出一种基于Volk角膜接触透镜的免散瞳广域视网膜成像系统。照明充分时，Volk镜头能够达到130°以上的视场。在传统眼底相机的基础上改进照明方式, 采用外部环形光纤照明的方式实现视网膜广域照明。增大入射角度消除鬼像的影响，同时避免由环形照明方式导致的中心区域的暗斑现象，被照亮的眼底图像经过接目物镜组消除眼角膜反射造成的杂光并采用手动调焦的方式在CMOS相机上成现清晰的像。图像采集使用(2/3)英寸板面彩色CMOS相机并且实时上传至电脑客户端进行分析、处理、存档等操作，经过后期图像处理后可为各类眼科疾病的诊断、筛查提供清晰、客观的依据。
- 广域成像 /
- 视网膜图像采集 /
- 环形照明
Abstract: In view of the traditional fundus camera which can not check the defects of retinal edge, a non-mydriatic wide-area retinal imaging system based on Volk contact lens is proposed.In sufficient lighting conditions, Volk lens can reach more than 130° field of view(FOV).The illumination way is improved based on traditional fundus camera, and by the way of using external annular fiber illumination, the retinal wide-area illumination is realized. The incident angle is increased to eliminate the influence of ghost image, and the dark spot phenomenon in center region can be avoided which is caused by annular lighting meanwhile.The objective lens group eliminates the stray light caused by the corneal reflex and uses the manual focusing method to make a clear image on the complementary metal-oxide semiconductor (CMOS) camera.The fundus images are collected by the colorized CMOS camera with (2/3)′ image acquisition board and then uploaded to the PC terminal in real-time for analyzing, processing, archiving and other operations.Images after post-processing can provide clear, objective bases for the diagnosis and screening of varied kinds of eye diseases.
- wide-area imaging /
- retinal image acquisition /
- annular illumination

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图 1 眼底相机原理图

Figure 1. Schematic diagram of fundus camera

下载: 全尺寸图片幻灯片

图 2 不同视场成像光束的入瞳(TEP)

Figure 2. Entrance pupil of imaging beam withdifferent FOVs(TEP)

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图 3 成像视场示意图

Figure 3. Schematic view of imaging field

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图 4 成像光路示意图

Figure 4. Schematic diagram of imaging light path

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图 5 成像暗区与总入瞳和角膜视窗的关系

Figure 5. Relationship among dark area ofimaging, TEP and CW

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图 6 照明视场

Figure 6. Lighting fields

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图 7 LightTools光路追迹

Figure 7. Ray tracing by LightTools

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图 8 基于Android系统的实验平台搭建及(b)模拟眼测试结果

Figure 8. Experimental platform based on Android system and (b) test results with model eye

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表 1 瞳孔为7 mm时激光单次曝光保护标准

Table 1 Protection standard of laser single exposurewhen pupil is 7 mm

曝光时间t/s	保护标准/(J/cm ²)
10 ^-9~18×10 ^-6	0.5×10 ^-6
18×10 ^-6~10	1.8×10 ^-3 t ^5/4
10~10 ⁴	10 ^-2
10 ⁴~3×10 ⁴	10 ^-6 t

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表 2 漫反射和扩展源曝光保护标准

Table 2 Protection standard of diffuse reflection andexposure of extended source

曝光时间t/s	漫反射面辐照度/(J/cm ²)	扩散源面辐照度/(J/cm ²)
10 ^-9~10	10π t ^1/3	10π t ^1/3/δ
10~10 ⁴	20π	20/δ
10 ⁴~3×10 ⁴	2π×10 ^-3 t	2×10 ^-3/δ

下载: 导出CSV

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