Abstract: In order to implement blind-pixel compensation for IRFPA in omni-directional laser warning system, a new weighted interpolation algorithm based on neighborhood grey character is presented. The impact of blind-pixel on the system was analyzed, the basic concept and principle of the algorithm were elaborated and analyzed, and the algorithm was verified by experimental simulation. Finally, the blind-pixel compensation result was evaluated subjectively and objectively. Compared with the conventional algorithms of neighborhood averaging and mid-value filter, the new algorithm is more suitable for the blind-pixel compensation of omni-directional laser warning system. The blind-pixel compensation offset of the new algorithm is smaller than those of the other two algorithms, and it reduces the impact of blind-pixel influence on the system, which can improve the system working performance effectively.