Abstract: One design method of aspherical intraocular lens (AIOL) was presented. Based on the corneal model of Holladay, the spherical aberration of the cornea was set as the SA value of the AIOL. The optical performances of aspherical and spherical IOL were analyzed comparatively when the IOL moved forward and the pupil diameter changed. As a result, the MTF, contrast sensitivity and off focus MTF of the eye implanted with aspherical IOL designed by this method were better than those of spherical IOL when the implanted position and the pupil diameter were the same. The imaging quality of the eye decreased with the pupil diameter as the IOL moved forward, the MTF of the eyes decreased with the pupil diameter. However, the aspherical IOL still presented more excellent optical performance than traditional spherical IOL.