光动力疗法中光动力剂量的数学仿真研究

徐朝辉; 贺庆丽

光动力疗法中光动力剂量的数学仿真研究

徐朝辉^1,2, ,,
贺庆丽¹

1.
西北大学物理学系,陕西西安,710069;
2.
周口师范学院物理学系,河南周口,466001

详细信息

通讯作者:
徐朝辉(1978-)男，陕西华县人，硕士研究生，主要从事生物光子学方面的研究工作。

中图分类号: TN249
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出版历程
- 刊出日期: 2010-05-14

Photodynamic dose of photodynamic therapy by mathematical simulation

XU Zhao-hui^1,2, ,,
HE Qing-li¹

1.
Department of Physics,Northwest University,Xi’an 710069,China;
2.
Department of Physics,Zhoukou Normal Univesity,Zhoukou 466001,China

摘要

摘要: 通过建立光动力治疗过程中激光、光敏剂、氧及其相互作用关系的数学模型，对组织中光动力剂量进行了模拟，研究了光动力剂量在组织内部分布变化的规律。模拟了激光剂量为50mW/cm2、100mW/cm2、150mW/cm2，光敏剂质量浓度为10mg/kg、20mg/kg、40mg/kg时光动力剂量变化。研究发现光动力剂量在组织内分布是非线性的，大小受激光强度、光敏剂剂量、氧浓度和组织光学参数等因素的影响，且光敏剂浓度的变化对光动力剂量变化的影响尤为明显。
- 光动力疗法 /
- 肿瘤组织 /
- 光动力剂量 /
- 光漂白
Abstract: Through establishing mathematical relation model of laser, photo-sensitizer and oxygen, photodynamic dose (PDD) in tissue was simulated and its distribution was studied. The change of PDD under the different laser doses of 50mW/cm2，100mW/cm2 and 150mW/cm2 and the photo-sensitizer concentrations of 10mg/kg，20mg/kg and 40mg/kg were simulated. It is concluded that the PDD, an inhomogeneous value in the tissue, changes with many factors such as laser dose, photo-sensitizer and oxygen, and it is obviously effected by the variation of photo-sensitizer concentration.
- photodynamic therapy /
- tissue /
- PDD /
- photo-bleaching

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参考文献(1)

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［2］李忠明,张镇西.光动力作用效果的剂量学描述探讨［J］.激光杂志,2005,26(5):91-92.
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文章访问数: 2614
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光动力疗法中光动力剂量的数学仿真研究

通讯作者:
徐朝辉(1978-)男，陕西华县人，硕士研究生，主要从事生物光子学方面的研究工作。

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Photodynamic dose of photodynamic therapy by mathematical simulation

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光动力疗法中光动力剂量的数学仿真研究

通讯作者: 徐朝辉(1978-)男，陕西华县人，硕士研究生，主要从事生物光子学方面的研究工作。

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Photodynamic dose of photodynamic therapy by mathematical simulation

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通讯作者:
徐朝辉(1978-)男，陕西华县人，硕士研究生，主要从事生物光子学方面的研究工作。