Abstract: In order to achieve the long-distance real-time transmission of image fusion system, a high-speed network transmission image fusion system design scheme based on TI TMS320DM642 and TMS320DM365 processors was presented. Fusion module based on TMS320DM642 and net transmission module based on TMS320DM365 were designed, and the data communication problem between the image fusion module and net transmission module was solved. Image registration and real-time image fusion were achieved in fusion module. Image data was compressed by H.264 algorithm and carried out real-time transport protocol (RTP) packet processing according to RTP protocol in net transmission module, and the transmission rate was about 460 kb/s. Using thread pipe communication technology, a new establishment method based on RTP/real time streaming protocol (RTSP) embedded streaming media server was achieved. Experimental results show that the overall system image delay is about 300 ms.