Abstract: The commonly-used single vision lens has the problem of variational refractive power when it is worn and actually perceived. Response to this problem, a new design method based on lens-eye joint model for single vision lens was proposed. According to the new design method, the variational visual angles were matched to different areas of lens, and the constant perceived diopter on the corneal surface was set as precondition. The diopter on the lens surface was recomputed, and finally the diopter distribution and the corresponding surface shape data were obtained. Based on the proposed design method, the diopter of −6.00 D actually felt on the corneal surface was taken as an example to generate surface shape data for lens manufacturing, and the surface shape and diopter of the manufactured lens were measured and evaluated. The test results show that the central diopter of the manufactured lens is −6.30 D, the diopter values gradually vary from the center to the edge of the manufactured lens, and the maximum diopter error is smaller than ±0.23 D, which verifies the effectiveness of the proposed designed method.