Abstract: In the process of assembling and adjusting the infrared optical lens group, the optical center-deviation will occur. Since the infrared material is not transparent to visible light, the traditional visible light adjustment mode cannot be used, which becomes a difficulty in the assembly and adjustment of the infrared lens group. An assembly and adjustment scheme based on the OptiCentric dual-optical path center-deviation measuring instrument from TRIOPTIC company in Germany was proposed, and introduced in detail the assembly and adjustment methods of no-mirror seat centering method, the mirror seat method and the aspheric surface. The advantages and disadvantages of the no-mirror seat centering method and the mirror seat method were analyzed. In addition, it was pointed out that there were still some limitations in the centering of aspheric surfaces using the OptiCentric center-deviation measuring instrument. Finally, the optical transfer function tester was used to test the lens adjusted by the above two methods. The test results show that the lens adjusted by the center-deviation measuring instrument can meet the requirements of technical indicators.