Abstract: The improved image correlation computing method was adopted. On the basis of accurate registration of images before and after interference, the image correlation was computed in pixels, the interference threshold was determined according to the human eye recognition effect, the statistic value of image effective interference pixels was calculated, and the laser interference effect was quantitatively described. The experiments of multi-band laser interference imaging system were carried out, and the laser interference images under different interference power were collected to evaluate the interference effect. The results show that the proposed method can accurately identify the local changes of the images, objectively reflect the image quality changes, and give scientific evaluation results for the laser interference imaging images under different power in each band, and the processing speed of a single pair of images is better than the second level, which has certain engineering application value.