Abstract: According to the requirement of stabilization precision of 0.2 mrad for artillery aiming line in upper anti-stabilization aiming system, a multi-closed control loop was formed by adding high gain acceleration closed-loop correction in traditional inertia rate stable closed-loop, and the PID parameters of the system were adjusted by integral of time-weight absolute error (ITAE) optimal control. The structure of the upper anti-stabilization aiming system was introduced and analyzed, and the closed-loop control system was simulated, such as load, gyro and brushless torque motor. The ITAE optimal controller was used to adjust the PID control parameters of the multi-closed-loop control system. Added random interference and unit step response to the system in order to test the related performance. The test results show that compared with the traditional adjustment of PID parameters and single-speed-loop control system, the multi-closed-loop ITAE optimal controller based on acceleration can improve the system anti-disturbance performance by 78%, the overshoot is reduced by about 23%, and the swing stability accuracy is improved by about 29%, which can better meet the stability requirements of the upper anti-stabilization aiming system.