Abstract: Aiming at the problem of carrier vibration, system parameter perturbation, friction torque and external disturbance in photoelectric tracking and stabilization platform system that directly affect the stability accuracy of photoelectric tracking system, the deviation in the tracking system was suppressed from the servo controller control perspective to improve the stability accuracy and ensure its strong robustness in the complex environment. By establishing the mathematical model of the photoelectric tracking and stabilization platform system, the influence of disturbance torque, gyro noise and system parameter changes on the photoelectric tracking and stabilization platform was analyzed, and the compound control strategy based on the novel nonlinear extended state observer (NNESO) and sliding mode variable structure control (SMVSC) was designed. The results of theoretical derivation and simulation experiments show that this kind of compound control strategy has full adaptability and strong robustness to disturbance torque, external disturbance and system parameter perturbation. At the same time, compared with the control system without the novel nonlinear extended state observer, it proves that the compound control strategy has higher stability accuracy and faster dynamic response, which has good effect in compensating the nonlinearity and can enhance the anti-disturbance ability of the photoelectric tracking and stabilization platform.