Abstract: Aiming at the condition that the imaging object does not exceed the memory effect range of the scattering medium, a method combining digital off-axis holography to reduce the speckle autocorrelation noise in the imaging of the scattering medium was proposed. When the imaging target passed through the scattering medium, the autocorrelation technique combined with the phase recovery algorithm could reconstruct the imaging target from the speckle. However, in the actual imaging process, in order to effectively suppress the influence of environmental noise and thermal noise on the reconstruction effect, the design used the phase shift method in off-axis holography to eliminate the interference of the static noise item in the noise item, and then used the speckle autocorrelation and the phase recovery algorithm reconstructed the imaging target with better effect after denoising. The structural similarity was used to quantitatively evaluate the reconstruction effect. The simulation results show that for the given imaging target, the structural similarity before and after denoising increases from 0.879 6 to 0.987 5, which verifies the effectiveness of the method. It shows that the proposed method can improve the reconstruction effect of speckle autocorrelation method.