Abstract: To study the stabilization precision and avoid deducing the complicate dynamic equation of multi-gimbal electro-optic stabilization system, a method for structure-control co-simulation using Matlab and ADAMS was developed. The step response of azimuth and elevation axes, the line-of-sight(LOS) angular velocity in inertial space under triaxis base linear vibration ,and the LOS stabilization precision under tri-axis base angular motion of 2° and 1 Hz were studied. The simulation results and the qualitative analysis are consistent， indicating that the method is useful and can be applied for new product development.